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A role for DNA primase in coupling DNA replication to DNA damage response.

The temperature-sensitive yeast DNA primase mutant pri1-M4 fails to execute an early step of DNA replication and exhibits a dominant, allele-specific sensitivity to DNA-damaging agents. pri1-M4 is defective in slowing down the rate of S phase progression and partially delaying the G1-S transition in...

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Autors principals: Marini, F, Pellicioli, A, Paciotti, V, Lucchini, G, Plevani, P, Stern, D F, Foiani, M
Format: Artigo
Idioma:Inglês
Publicat: 1997
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1169666/
https://ncbi.nlm.nih.gov/pubmed/9034345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.3.639
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