Parvovirus Nonstructural Proteins Induce an Epigenetic Modification through Histone Acetylation in Host Genes and Revert Tumor Malignancy to Benignancy

Several malignant tumor cells become apoptotic and revert to the benign phenotype upon parvovirus infection. Recently, we demonstrated that the rat parvovirus RPV/UT also induces apoptosis in the rat thymic lymphoma cell line C58(NT)D. However, a minority of cells that escaped apoptosis showed prope...

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Detalhes bibliográficos
Main Authors: Iseki, Hiroyoshi, Shimizukawa, Rie, Sugiyama, Fumihiro, Kunita, Satoshi, Iwama, Atsushi, Onodera, Masafumi, Nakauchi, Hiromitsu, Yagami, Ken-ichi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Transformation and Oncogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1168790/
https://ncbi.nlm.nih.gov/pubmed/15994782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.14.8886-8893.2005
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