Growth Suppression Induced by Downregulation of E6-AP Expression in Human Papillomavirus-Positive Cancer Cell Lines Depends on p53

The ubiquitin-protein ligase E6-AP is utilized by the E6 oncoprotein of human papillomaviruses (HPVs) associated with cervical cancer to target the tumor suppressor p53 for degradation. Here, we report that downregulation of E6-AP expression by RNA interference results in both the accumulation of p5...

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Main Authors: Hengstermann, Arnd, D'silva, Michael A., Kuballa, Petric, Butz, Karin, Hoppe-Seyler, Felix, Scheffner, Martin
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2005
Teme:
Transformation and Oncogenesis
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1168765/
https://ncbi.nlm.nih.gov/pubmed/15994823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.14.9296-9300.2005
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