A Human T-Cell Leukemia Virus Type 1 Regulatory Element Enhances the Immunogenicity of Human Immunodeficiency Virus Type 1 DNA Vaccines in Mice and Nonhuman Primates

Plasmid DNA vaccines elicit potent and protective immune responses in numerous small-animal models of infectious diseases. However, their immunogenicity in primates appears less potent. Here we investigate a novel approach that optimizes regulatory elements in the plasmid backbone to improve the imm...

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Detaylı Bibliyografya
Asıl Yazarlar: Barouch, Dan H., Yang, Zhi-yong, Kong, Wing-pui, Korioth-Schmitz, Birgit, Sumida, Shawn M., Truitt, Diana M., Kishko, Michael G., Arthur, Janelle C., Miura, Ayako, Mascola, John R., Letvin, Norman L., Nabel, Gary J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2005
Konular:
Vaccines and Antiviral Agents
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1168733/
https://ncbi.nlm.nih.gov/pubmed/15994776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.14.8828-8834.2005
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