Evaluation of a New Line Probe Assay for Rapid Identification of gyrA Mutations in Mycobacterium tuberculosis

Resistance of Mycobacterium tuberculosis to fluoroquinolones (FQ) results mostly from mutations in the gyrA gene. We developed a reverse hybridization-based line probe assay in which oligonucleotide probes carrying the wild-type gyrA sequence, a serine-to-threonine (S95T) polymorphism, and gyrA muta...

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Detalhes bibliográficos
Main Authors: Giannoni, Federico, Iona, Elisabetta, Sementilli, Federica, Brunori, Lara, Pardini, Manuela, Migliori, Giovanni Battista, Orefici, Graziella, Fattorini, Lanfranco
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1168684/
https://ncbi.nlm.nih.gov/pubmed/15980370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.7.2928-2933.2005
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