Certain Site-Directed, Nonenzymatically Active Mutants of the Haemophilus influenzae P4 Lipoprotein Are Able To Elicit Bactericidal Antibodies

The Haemophilus influenzae P4 lipoprotein (hel) is a potential component of a nontypeable H. influenzae otitis media vaccine. Since P4 is known to be an enzyme, nonenzymatically active forms of recombinant P4 are required. After site-directed mutagenesis of the hel gene, three of the mutated protein...

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Detalhes bibliográficos
Main Authors: Green, Bruce A., Baranyi, Elizabeth, Reilly, Thomas J., Smith, Arnold L., Zlotnick, Gary W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1168610/
https://ncbi.nlm.nih.gov/pubmed/15972549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.73.7.4454-4457.2005
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