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Binding of β-lactam antibiotics to the exocellular dd-carboxypeptidase–transpeptidase of Streptomyces R39

Benzylpenicillin and cephaloridine reacted with the exocellular dd-carboxypeptidase–transpeptidase from Streptomyces R39 to form equimolar and inactive antibiotic–enzyme complexes. At saturation, the molar ratio of chromogenic cephalosporin 87-312 to enzyme was 1.3:1, but this discrepancy might be d...

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Dettagli Bibliografici
Autori principali: Frère, Jean-Marie, Ghuysen, Jean-Marie, Reynolds, Peter E., Moreno, Ramon, Perkins, Harold R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1974
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1168372/
https://ncbi.nlm.nih.gov/pubmed/4464853
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