Reelin promoter hypermethylation in schizophrenia

Reelin mRNA and protein levels are reduced by ≈50% in various cortical structures of postmortem brain from patients diagnosed with schizophrenia or bipolar illness with psychosis. In addition, the mRNA encoding the methylating enzyme, DNA methyltransferase 1, is up-regulated in the same neurons that...

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Bibliographic Details
Main Authors: Grayson, Dennis R., Jia, Xiaomei, Chen, Ying, Sharma, Rajiv P., Mitchell, Colin P., Guidotti, Alessandro, Costa, Erminio
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2005
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1166626/
https://ncbi.nlm.nih.gov/pubmed/15961543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0503736102
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