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The mechanism of C-4 demethylation during cholesterol biosynthesis. Evidence for a decarboxylation mechanism not involving a Schiff-base intermediate

The conversion of 4,4-dimethylcholest-7-enol into 4α-methylcholest-7-enol by rat liver microsomal preparations involves the decarboxylation of a sterol 3-oxo-4α-carboxylic acid. By using an (18)O-labelled substrate it was shown that this decarboxylation does not involve a Schiff-base intermediate.

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Detalles Bibliográficos
Main Authors: Wilton, D. C., Akhtar, M.
Formato: Artigo
Idioma:Inglês
Publicado: 1975
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1165609/
https://ncbi.nlm.nih.gov/pubmed/242323
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