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The inhibition of β-lactamases from Gram-negative bacteria by clavulanic acid
The β-lactamase from Klebsiella pneumoniae E70 behaved in a similar fashion to the TEM-2 plasmid mediated enzyme on reaction with clavulanic acid. Both enzymes produced two types of enzyme–clavulanate complex, a transiently stable species (t(½)=4min at pH7.3 and 37°C) and irreversibly inhibited enzy...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
1981
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1163436/ https://ncbi.nlm.nih.gov/pubmed/7041890 |
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