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Isotope-dilution analysis of the effects of deoxyguanosine and deoxyadenosine on the incorpoŕation of thymidine and deoxycytidine by hydroxyurea-treated thymus cells

It is presumed that the dGTP and dATP needed for replicative DNA synthesis can be formed by way of either `salvage' pathways or biosynthesis de novo. This was examined by adding hydroxyurea to cultures of rat thymus cells to inhibit ribonucleoside diphosphate reductase, a key enzyme of the `de...

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Detalles Bibliográficos
Main Authors: Scott, Fraser W., Forsdyke, Donald R.
Formato: Artigo
Idioma:Inglês
Publicado: 1980
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1162152/
https://ncbi.nlm.nih.gov/pubmed/6970575
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