Genetic Immunization of Wild-Type and Hepatitis C Virus Transgenic Mice Reveals a Hierarchy of Cellular Immune Response and Tolerance Induction against Hepatitis C Virus Structural Proteins

To study the effect of genetic immunization on transgenic expression of hepatitis C virus (HCV) proteins, we evaluated the immunological response of HCV transgenic mice to HCV expression plasmids. FVB/n transgenic mice expressing HCV structural proteins (core, E1, and E2) and wild-type (WT) FVB/n mi...

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Autors principals: Satoi, Jujin, Murata, Kazumoto, Lechmann, Martin, Manickan, Elanchezhiyan, Zhang, Zhensheng, Wedemeyer, Heiner, Rehermann, Barbara, Liang, T. Jake
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2001
Matèries:
Vaccines and Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC116108/
https://ncbi.nlm.nih.gov/pubmed/11711603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.24.12121-12127.2001
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