Studies of Human MDR1-MDR2 Chimeras Demonstrate the Functional Exchangeability of a Major Transmembrane Segment of the Multidrug Transporter and Phosphatidylcholine Flippase

P-glycoprotein (P-gp), encoded by the MDR1 gene, is a plasma membrane transporter which effluxes a large number of structurally nonrelated hydrophobic compounds. The molecular basis of the broad substrate recognition of P-gp is not well understood. Despite the 78% amino acid sequence identity of the...

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Bibliografische gegevens

Gepubliceerd in:	Mol Cell Biol
Hoofdauteurs:	Zhou, Yi, Gottesman, Michael M., Pastan, Ira
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Taylor & Francis 1999
Onderwerpen:	Cell Growth and Development
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC116073/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9891078/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.19.2.1450
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