A Single Amino Acid Substitution in the v-Eyk Intracellular Domain Results in Activation of Stat3 and Enhances Cellular Transformation

The receptor tyrosine kinase Eyk, a member of the Axl/Tyro3 subfamily, activates the STAT pathway and transforms cells when constitutively activated. Here, we compared the potentials of the intracellular domains of Eyk molecules derived from c-Eyk and v-Eyk to transform rat 3Y1 fibroblasts. The v-Ey...

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Publié dans:	Mol Cell Biol
Auteurs principaux:	Besser, Daniel, Bromberg, Jacqueline F., Darnell, James E., Hanafusa, Hidesaburo
Format:	Artigo
Langue:	Inglês
Publié:	Taylor & Francis 1999
Sujets:	Cell Growth and Development
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC116068/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9891073/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.19.2.1401
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