Mechanism of force inhibition by 2,3-butanedione monoxime in rat cardiac muscle: roles of [Ca2+]i and cross-bridge kinetics.

1. We investigated the mechanism of force inhibition by 2,3-butanedione monoxime (BDM) on rat cardiac trabeculae. [Ca2+]i was measured by iontophoretic injection of fura-2 salt. Isometric force was recorded at an end-systolic sarcomere length of 2.1-2.2 microns. 2. With an external [Ca2+] of 1 mM, p...

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Bibliographic Details
Main Authors: Backx, P H, Gao, W D, Azan-Backx, M D, Marban, E
Format: Artigo
Language:Inglês
Published: 1994
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1160462/
https://ncbi.nlm.nih.gov/pubmed/8057256
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