A functional CFTR protein is required for mouse intestinal cAMP-, cGMP- and Ca(2+)-dependent HCO3- secretion.

1. Most segments of the gastrointestinal tract secrete HCO3-, but the molecular nature of the secretory mechanisms has not been identified. We had previously speculated that the regulator for intestinal electrogenic HCO3- secretion is the cystic fibrosis transmembrane regulator (CFTR) channel. To pr...

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Main Authors: Seidler, U, Blumenstein, I, Kretz, A, Viellard-Baron, D, Rossmann, H, Colledge, W H, Evans, M, Ratcliff, R, Gregor, M
Formato: Artigo
Idioma:Inglês
Publicado: 1997
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1160074/
https://ncbi.nlm.nih.gov/pubmed/9423183
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