Endothelin-1 potently stimulates chloride secretion and inhibits Na(+)-glucose absorption in human intestine in vitro.

1. Serosally added synthetic endothelin-1 (ET-1) increased short-circuit current (Isc) across isolated muscle-stripped human colonic mucosa in vitro. Bumetanide inhibited Isc responses, indicating that ET-1 stimulates electrogenic Cl- secretion. 2. In isolated human jejunal mucosa, ET-1 exhibited a...

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Detalhes bibliográficos
Main Authors: Kuhn, M, Fuchs, M, Beck, F X, Martin, S, Jähne, J, Klempnauer, J, Kaever, V, Rechkemmer, G, Forssmann, W G
Formato: Artigo
Idioma:Inglês
Publicado em: 1997
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1159314/
https://ncbi.nlm.nih.gov/pubmed/9080369
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