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Simian Immunodeficiency Virus (SIV) Infection of a Rhesus Macaque Induces SIV-Specific CD8(+) T Cells with a Defect in Effector Function That Is Reversible on Extended Interleukin-2 Incubation

A vigorous expansion of antigen-specific CD8(+) T cells lacking apparent effector function was observed in a rhesus macaque acutely infected with the simian immunodeficiency virus (SIV) strain SIVmac239. Antigen-specific CD8(+) T cells were identified using antigenic-peptide class I major histocompa...

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Udgivet i:J Virol
Principais autores: Xiong, Yelin, Luscher, Mark A., Altman, John D., Hulsey, Michael, Robinson, Harriet L., Ostrowski, Mario, Barber, Brian H., MacDonald, Kelly S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2001
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC115931/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11222730/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.6.3028-3033.2001
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