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Exchange of the Basic Domain of Human Immunodeficiency Virus Type 1 Rev for a Polyarginine Stretch Expands the RNA Binding Specificity, and a Minimal Arginine Cluster Is Required for Optimal RRE RNA Binding Affinity, Nuclear Accumulation, and trans-Activation

The Rev regulatory protein of human immunodeficiency virus (HIV) facilitates the nuclear export of unspliced and partially spliced HIV RNAs. Using a Rev:MS2 phage coat protein fusion that could be targeted to bind and activate the Rev-responsive element (RRE) RNA or heterologous MS2 phage operator R...

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Publicado no:J Virol
Principais autores: Nam, Yong-Suk, Petrovic, Ana, Jeong, Kyu-Shik, Venkatesan, Sundararajan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2001
Assuntos:
Replication
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC115922/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11222721/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.6.2957-2971.2001
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