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Effect of 4-hydroxypyrazole on tryptophan and formate metabolism in isolated rat liver cells.

1. 4-Hydroxypyrazole inhibits flux through tryptophan 2.3-dioxygenase in cells. The inhibition is apparently non-competitive with Ki = 0.15 mM. 2. Hydroxypyrazole inhibits the oxidation of formate to CO2 in liver cells. 3. Glycollate, which generates H2O2, stimulates formate oxidation. This process...

詳細記述

保存先:
書誌詳細
主要な著者: Cook, J S, Pogson, C I
フォーマット: Artigo
言語:Inglês
出版事項: 1982
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1158346/
https://ncbi.nlm.nih.gov/pubmed/6810879
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