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NMR study of a membrane protein in detergent-free aqueous solution

One of the major obstacles to membrane protein (MP) structural studies is the destabilizing effect of detergents. Amphipols (APols) are short amphipathic polymers that can substitute for detergents to keep MPs water-soluble under mild conditions. In the present work, we have explored the feasibility...

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Autori principali: Zoonens, Manuela, Catoire, Laurent J., Giusti, Fabrice, Popot, Jean-Luc
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2005
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1157056/
https://ncbi.nlm.nih.gov/pubmed/15956183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0503750102
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