Activation of the SPHK/S1P signalling pathway is coupled to muscarinic receptor-dependent regulation of peripheral airways

BACKGROUND: In peripheral airways, acetylcholine induces contraction via activation of muscarinic M2-and M3-receptor subtypes (M(2)R and M(3)R). Cholinergic hypersensitivity is associated with chronic obstructive pulmonary disease and asthma, and therefore the identification of muscarinic signaling...

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Autores principales: Pfaff, Melanie, Powaga, Norbert, Akinci, Sibel, Schütz, Werner, Banno, Yoshiko, Wiegand, Silke, Kummer, Wolfgang, Wess, Jürgen, Haberberger, Rainer Viktor
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2005
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1156956/
https://ncbi.nlm.nih.gov/pubmed/15927078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-6-48
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