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Estimating haplotype frequencies in pooled DNA samples when there is genotyping error
BACKGROUND: Maximum likelihood estimates of haplotype frequencies can be obtained from pooled DNA using the expectation maximization (EM) algorithm. Through simulation, we investigate the effect of genotyping error on the accuracy of haplotype frequency estimates obtained using this algorithm. We ex...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BioMed Central
2005
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1156884/ https://ncbi.nlm.nih.gov/pubmed/15943883 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2156-6-25 |
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