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Interaction of clavulanate with the beta-lactamases of Streptomyces albus G and Actinomadura R39.

The reactions of beta-lactamases of Actinomadura R39 and Streptomyces albus G with clavulanate proceed along branched pathways. Both enzymes perform the hydrolysis of this beta-lactam with rather high efficiencies (kcat. = 18s-1 and 52s-1 respectively). If large clavulanate/enzyme ratios are used, c...

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Bibliografische gegevens
Hoofdauteurs: Frère, J M, Dormans, C, Lenzini, V M, Duyckaerts, C
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1982
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1153882/
https://ncbi.nlm.nih.gov/pubmed/6984651
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