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Extracts of human articular cartilage contain an inhibitor of tissue metalloproteinases.

When human articular cartilage is extracted with 2M-guanidinium hydrochloride at pH 7.5, an inhibitor is obtained that blocks the activity of three metalloproteinases, including collagenase. Molecular-sieve chromatography of the inhibitor gives an Mr value for the inhibitor of 28 500. The inhibitor...

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Hlavní autoři: Dean, D D, Woessner, J F
Médium: Artigo
Jazyk:Inglês
Vydáno: 1984
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1153334/
https://ncbi.nlm.nih.gov/pubmed/6370238
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