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HuD binds to three AU-rich sequences in the 3′-UTR of neuroserpin mRNA and promotes the accumulation of neuroserpin mRNA and protein

Neuroserpin is an axonally secreted serine protease inhibitor expressed in the nervous system that protects neurons from ischemia-induced apoptosis. Mutant neuroserpin forms have been found polymerized in inclusion bodies in a familial autosomal encephalopathy causing dementia, or associated with ep...

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Udgivet i:Nucleic Acids Res
Principais autores: Cuadrado, Ana, Navarro-Yubero, Cristina, Furneaux, Henry, Kinter, Jochen, Sonderegger, Peter, Muñoz, Alberto
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2002
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC115279/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12000840/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/30.10.2202
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