Dual effects of guanosine 5'-[gamma-thio]triphosphate on secretion by electroporated human neutrophils.

It is generally believed that G-proteins play stimulatory roles on cell activation. In contrast, we found that guanosine 5'-[gamma-thio]triphosphate (GTP[S]) was a potent inhibitor of Ca(2+)-induced secretion from specific granules (as monitored by vitamin B-12-binding protein). GTP[S] inhibiti...

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Bibliografiska uppgifter
Huvudupphovsmän: Smolen, J E, Stoehr, S J, Kuczynski, B, Koh, E K, Omann, G M
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1991
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1151495/
https://ncbi.nlm.nih.gov/pubmed/1953659
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