Influence of Mg2+ and pH on n.m.r. spectra and radioligand binding of inositol 1,4,5-trisphosphate.

We and others have shown that the binding of Ins(1,4,5)P3 to its receptor is pH-sensitive and can be inhibited by Mg2+. In the present study we have used 1H- and 31P-n.m.r. spectroscopy to study whether these effects results from increased ionization of Ins(1,4,5)P3 and a direct interaction with Mg2...

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Detalhes bibliográficos
Main Authors: White, A M, Varney, M A, Watson, S P, Rigby, S, Liu, C S, Ward, J G, Reese, C B, Graham, H C, Williams, R J
Formato: Artigo
Idioma:Inglês
Publicado em: 1991
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1151411/
https://ncbi.nlm.nih.gov/pubmed/1654891
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