Irreversible inhibition of rat glutathione S-transferase 1-1 by quinones and their glutathione conjugates. Structure-activity relationship and mechanism.

The irreversible inhibition of the rat glutathione S-transferase (GST) isoenzyme 1-1 by a series of halogenated 1,4-benzoquinones and their GSH conjugates was studied quantitatively by analysing the time course of enzyme inactivation. With increasing numbers of chlorine substituents, the rate of inh...

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Main Authors: van Ommen, B, Ploemen, J H, Bogaards, J J, Monks, T J, Gau, S S, van Bladeren, P J
Formato: Artigo
Idioma:Inglês
Publicado: 1991
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1151056/
https://ncbi.nlm.nih.gov/pubmed/2064604
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