DNA Vaccination with the Hantaan Virus M Gene Protects Hamsters against Three of Four HFRS Hantaviruses and Elicits a High-Titer Neutralizing Antibody Response in Rhesus Monkeys

Four hantaviruses—Hantaan virus (HTNV), Seoul virus (SEOV), Dobrava virus (DOBV) and Puumala virus—are known to cause hemorrhagic fever with renal syndrome (HFRS) in Europe and Asia. HTNV causes the most severe form of HFRS (5 to 15% case-fatality rate) and afflicts tens of thousands of people annua...

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Bibliographic Details
Main Authors: Hooper, J. W., Custer, D. M., Thompson, E., Schmaljohn, C. S.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2001
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC115092/
https://ncbi.nlm.nih.gov/pubmed/11507192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.18.8469-8477.2001
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