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Selective modification of alternative splicing by indole derivatives that target serine-arginine-rich protein splicing factors
The prevalence of alternative splicing as a target for alterations leading to human genetic disorders makes it highly relevant for therapy. Here we have used in vitro splicing reactions with different splicing reporter constructs to screen 4,000 chemical compounds for their ability to selectively in...
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| Hoofdauteurs: | , , , , , , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
National Academy of Sciences
2005
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1150812/ https://ncbi.nlm.nih.gov/pubmed/15939885 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409829102 |
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