Selective modification of alternative splicing by indole derivatives that target serine-arginine-rich protein splicing factors

The prevalence of alternative splicing as a target for alterations leading to human genetic disorders makes it highly relevant for therapy. Here we have used in vitro splicing reactions with different splicing reporter constructs to screen 4,000 chemical compounds for their ability to selectively in...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Soret, Johann, Bakkour, Nadia, Maire, Sophie, Durand, Sébastien, Zekri, Latifa, Gabut, Mathieu, Fic, Weronika, Divita, Gilles, Rivalle, Christian, Dauzonne, Daniel, Nguyen, Chi Hung, Jeanteur, Philippe, Tazi, Jamal
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2005
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC1150812/
https://ncbi.nlm.nih.gov/pubmed/15939885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409829102
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