Selective modification of alternative splicing by indole derivatives that target serine-arginine-rich protein splicing factors

The prevalence of alternative splicing as a target for alterations leading to human genetic disorders makes it highly relevant for therapy. Here we have used in vitro splicing reactions with different splicing reporter constructs to screen 4,000 chemical compounds for their ability to selectively in...

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Détails bibliographiques
Auteurs principaux: Soret, Johann, Bakkour, Nadia, Maire, Sophie, Durand, Sébastien, Zekri, Latifa, Gabut, Mathieu, Fic, Weronika, Divita, Gilles, Rivalle, Christian, Dauzonne, Daniel, Nguyen, Chi Hung, Jeanteur, Philippe, Tazi, Jamal
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2005
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1150812/
https://ncbi.nlm.nih.gov/pubmed/15939885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409829102
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