Further evidence that cyclosporin A protects mitochondria from calcium overload by inhibiting a matrix peptidyl-prolyl cis-trans isomerase. Implications for the immunosuppressive and toxic effects of cyclosporin.

The Ki values of cyclosporins A, G and H for the peptidyl-prolyl cis-trans isomerase (PPIase) of liver and heart mitochondria are about 2, 20 and 500 nM respectively. This parallels their profile as inhibitors of non-specific pore opening of mitochondria induced by supraphysiological Ca2+ concentrat...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Griffiths, E J, Halestrap, A P
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 1991
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC1150183/
https://ncbi.nlm.nih.gov/pubmed/1706598
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