Binding of Human Immunodeficiency Virus Type 1 gp120 to CXCR4 Induces Mitochondrial Transmembrane Depolarization and Cytochrome c-Mediated Apoptosis Independently of Fas Signaling

Apoptosis of CD4(+) T lymphocytes, induced by contact between human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (gp120) and its receptors, could contribute to the cell depletion observed in HIV-infected individuals. CXCR4 appears to play an important role in gp120-induced cell death,...

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Main Authors: Roggero, Rodolphe, Robert-Hebmann, Véronique, Harrington, Steve, Roland, Joachim, Vergne, Laurence, Jaleco, Sara, Devaux, Christian, Biard-Piechaczyk, Martine
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC114999/
https://ncbi.nlm.nih.gov/pubmed/11462036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.16.7637-7650.2001
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