Syncatalytic inactivation of prolyl 4-hydroxylase by anthracyclines.

The anthracyclines doxorubicin and daunorubicin were found to act as irreversible inhibitors of prolyl 4-hydroxylase. The reaction rate for enzyme from both chick and human origin was first order, the concentration of inhibitor giving 50% inhibition being 60 microM for both compounds after 1 h. The...

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Bibliografske podrobnosti
Main Authors: Günzler, V, Hanauske-Abel, H M, Myllylä, R, Kaska, D D, Hanauske, A, Kivirikko, K I
Format: Artigo
Jezik:Inglês
Izdano: 1988
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1149011/
https://ncbi.nlm.nih.gov/pubmed/2840891
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