A Single Amino Acid Substitution in Nonstructural Protein 3A Can Mediate Adaptation of Foot-and-Mouth Disease Virus to the Guinea Pig

The genetic changes selected during the adaptation of a clonal population of foot-and-mouth disease virus (FMDV) to the guinea pig have been analyzed. FMDV clone C-S8c1 was adapted to the guinea pig by serial passage in the animals until secondary lesions were observed. Analysis of the virus directl...

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Pubblicato in:	J Virol
Autori principali:	Núñez, Jose Ignacio, Baranowski, Eric, Molina, Nicolas, Ruiz-Jarabo, Carmen M., Sánchez, Carmen, Domingo, Esteban, Sobrino, Francisco
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2001
Soggetti:	Pathogenesis and Immunity
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC114889/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11264387/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.8.3977-3983.2001
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