A Single Amino Acid Substitution in Nonstructural Protein 3A Can Mediate Adaptation of Foot-and-Mouth Disease Virus to the Guinea Pig

The genetic changes selected during the adaptation of a clonal population of foot-and-mouth disease virus (FMDV) to the guinea pig have been analyzed. FMDV clone C-S8c1 was adapted to the guinea pig by serial passage in the animals until secondary lesions were observed. Analysis of the virus directl...

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Bibliographische Detailangaben
Hauptverfasser: Núñez, Jose Ignacio, Baranowski, Eric, Molina, Nicolas, Ruiz-Jarabo, Carmen M., Sánchez, Carmen, Domingo, Esteban, Sobrino, Francisco
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2001
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC114889/
https://ncbi.nlm.nih.gov/pubmed/11264387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.8.3977-3983.2001
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