Resensitization of hepatocyte glucagon-stimulated adenylate cyclase can be inhibited when cyclic AMP phosphodiesterase inhibitors are used to elevate intracellular cyclic AMP concentrations to supraphysiological values.

Eitemau Tebyg

• N6-(Phenylisopropyl)adenosine prevents glucagon both blocking insulin's activation of the plasma-membrane cyclic AMP phosphodiesterase and uncoupling hormonal stimulation of adenylate cyclase activity in hepatocytes.
  gan: Wallace, A V, et al.
  Cyhoeddwyd: (1984)
• An assessment of the ability of insulin-stimulated cyclic AMP phosphodiesterase to decrease hepatocyte intracellular cyclic AMP concentrations.
  gan: Heyworth, C M, et al.
  Cyhoeddwyd: (1984)
• The action of islet activating protein (pertussis toxin) on insulin's ability to inhibit adenylate cyclase and activate cyclic AMP phosphodiesterases in hepatocytes.
  gan: Heyworth, C M, et al.
  Cyhoeddwyd: (1986)
• Adenylate cyclase and cyclic AMP phosphodiesterase in Bradyrhizobium japonicum bacteroids.
  gan: Catanese, C A, et al.
  Cyhoeddwyd: (1989)
• Insulin and glucagon regulate the activation of two distinct membrane-bound cyclic AMP phosphodiesterases in hepatocytes.
  gan: Heyworth, C M, et al.
  Cyhoeddwyd: (1983)