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Resensitization of hepatocyte glucagon-stimulated adenylate cyclase can be inhibited when cyclic AMP phosphodiesterase inhibitors are used to elevate intracellular cyclic AMP concentrations to supraphysiological values.

Treatment of intact hepatocytes with glucagon led to the rapid desensitization of adenylate cyclase, which reached a maximum around 5 min after application of glucagon, after which resensitization ensued. Complete resensitization occurred some 20 min after the addition of glucagon. In hepatocytes wh...

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Bibliografische gegevens
Hoofdauteurs: Murphy, G J, Houslay, M D
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1988
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1148736/
https://ncbi.nlm.nih.gov/pubmed/2449179
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