Human Immunodeficiency Virus Type 1 Nef-Induced CD4 Cell Surface Downregulation Is Inhibited by Ikarugamycin

One well-characterized in vitro function of Nef is its ability to remove CD4, the human immunodeficiency virus (HIV) receptor, from the cell surface. Nef accomplishes this by accelerating the internalization and degradation of CD4. Current models propose that Nef promotes CD4 internalization via an...

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Detalhes bibliográficos
Main Authors: Luo, Tianci, Fredericksen, Brenda L., Hasumi, Keiji, Endo, Akira, Garcia, J. Victor
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC114835/
https://ncbi.nlm.nih.gov/pubmed/11160755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.5.2488-2492.2001
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