Nucleotide ligands protect the inter-domain regions of the multifunctional polypeptide CAD against limited proteolysis, and also stabilize the thermolabile part-reactions of the carbamoyl-phosphate synthase II domains within the CAD polypeptide.

Lignende værker

• The human Rad9 checkpoint protein stimulates the carbamoyl phosphate synthetase activity of the multifunctional protein CAD
  af: Lindsey-Boltz, Laura A., et al.
  Udgivet: (2004)
• Direct demonstration of carbamoyl phosphate formation on the C-terminal domain of carbamoyl phosphate synthetase
  af: Kothe, Michael, et al.
  Udgivet: (2005)
• Novel mechanism for carbamoyl-phosphate synthetase: A nucleotide switch for functionally equivalent domains
  af: Kothe, Michael, et al.
  Udgivet: (1997)
• Mammalian aspartate transcarbamylase (ATCase): sequence of the ATCase domain and interdomain linker in the CAD multifunctional polypeptide and properties of the isolated domain.
  af: Simmer, J P, et al.
  Udgivet: (1989)
• Mammalian aspartate transcarbamylase (ATCase): Sequence of the ATCase domain and interdomain linker in the CAD multifunctional polypeptide and properties of the isolated domain
  Udgivet: (1989)