Viral Evolution toward Change in Receptor Usage: Adaptation of a Major Group Human Rhinovirus To Grow in ICAM-1-Negative Cells

Major receptor group common cold virus HRV89 was adapted to grow in HEp-2 cells, which are permissive for minor group human rhinoviruses (HRVs) but which only marginally support growth of major-group viruses. After 32 blind passages in these cells, each alternating with boosts of the recovered virus...

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Main Authors: Reischl, Andrea, Reithmayer, Manuela, Winsauer, Gabriele, Moser, Rosita, Gösler, Irene, Blaas, Dieter
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2001
Assuntos:
Virus-Cell Interactions
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC114499/
https://ncbi.nlm.nih.gov/pubmed/11533194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.19.9312-9319.2001
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