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Surface-simulation synthesis of the substrate-binding site of an enzyme. Demonstration with trypsin.
From the X-ray co-ordinates of bovine trypsin and its complexes with substrate analogues (benzamidine) and with soya-bean trypsin inhibitor, a peptide (TP) was designed and synthesized by surface-simulation synthesis, a concept previously introduced by this laboratory, to mimic the binding site of t...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
1985
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1144735/ https://ncbi.nlm.nih.gov/pubmed/3994669 |
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