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Effects of deuterium substitution alpha and beta to the reaction centre, 18O substitution in the leaving group, and aglycone acidity on hydrolyses of aryl glucosides and glucosyl pyridinium ions by yeast alpha-glucosidase. A probable failure of the antiperiplanar-lone-pair hypothesis in glycosidase catalysis.

Neither kcat. nor kcat./Km for five aryl alpha-D-glucopyranosides correlates with aglycone pKa, and isotope effects, described according to the convention used by Cleland [(1982) CRC Crit. Rev. Biochem. 13, 385-428], of 18(V) = 1.002 +/- 0.008, alpha D(V) = 1.01 +/- 0.04 and alpha D(V/K) = 0.969 +/-...

詳細記述

保存先:
書誌詳細
主要な著者: Hosie, L, Sinnott, M L
フォーマット: Artigo
言語:Inglês
出版事項: 1985
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1144730/
https://ncbi.nlm.nih.gov/pubmed/3888191
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