Calcium and calmodulin in the regulation of human thyroid adenylate cyclase activity.

TSH (thyrotropin)-stimulated human thyroid adenylate cyclase has a biphasic response to Ca2+, being activated by submicromolar Ca2+ (optimum 22nM), with inhibition at higher concentrations. Calmodulin antagonists caused an inhibition of TSH-stimulated adenylate cyclase in a dose-dependent manner. In...

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Dettagli Bibliografici
Autori principali: Lakey, T, Mac Neil, S, Humphries, H, Walker, S W, Munro, D S, Tomlinson, S
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1985
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1144632/
https://ncbi.nlm.nih.gov/pubmed/3977849
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