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Abundant Early Expression of gpUL4 from a Human Cytomegalovirus Mutant Lacking a Repressive Upstream Open Reading Frame

The human cytomegalovirus UL4 gene encodes a 48-kDa glycoprotein, expression of which is repressed at the translational level by a short upstream open reading frame (uORF2) within the UL4 transcript leader. Mutation of the uORF2 initiation codon in the viral genome eliminates ribosomal stalling at t...

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Autors principals: Alderete, John P., Child, Stephanie J., Geballe, Adam P.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2001
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC114448/
https://ncbi.nlm.nih.gov/pubmed/11435600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.15.7188-7192.2001
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