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Formation of cytochrome P-450 containing haem or cobalt-protoporphyrin in liver homogenates of rats treated with phenobarbital and allylisopropylacetamide.

The potent porphyrogen allylisopropylacetamide and related compounds decrease hepatic concentrations of cytochrome P-450. This decrease occurs particularly in phenobarbital-induced cytochrome P-450 and is caused by suicidal breakdown of the haem of cytochrome P-450. Quantitative rocket immunoelectro...

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Main Authors: Bonkovsky, H L, Sinclair, J F, Healey, J F, Sinclair, P R, Smith, E L
格式: Artigo
語言:Inglês
出版: 1984
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1144199/
https://ncbi.nlm.nih.gov/pubmed/6477526
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