Single Point Mutations in the Zinc Finger Motifs of the Human Immunodeficiency Virus Type 1 Nucleocapsid Alter RNA Binding Specificities of the Gag Protein and Enhance Packaging and Infectivity

A specific interaction between the nucleocapsid (NC) domain of the Gag polyprotein and the RNA encapsidation signal (Ψ) is required for preferential incorporation of the retroviral genomic RNA into the assembled virion. Using the yeast three-hybrid system, we developed a genetic screen to detect hum...

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Detalhes bibliográficos
Main Authors: Mark-Danieli, Michal, Laham, Nihay, Kenan-Eichler, Michal, Castiel, Asher, Melamed, Daniel, Landau, Meytal, Bouvier, Nicole M., Evans, Matthew J., Bacharach, Eran
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1143677/
https://ncbi.nlm.nih.gov/pubmed/15919928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.12.7756-7767.2005
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