Immunization of Macaques with Single-Cycle Simian Immunodeficiency Virus (SIV) Stimulates Diverse Virus-Specific Immune Responses and Reduces Viral Loads after Challenge with SIV(mac)239

Genetically engineered simian immunodeficiency viruses (SIV) that is limited to a single cycle of infection was evaluated as a nonreplicating AIDS vaccine approach for rhesus macaques. Four Mamu-A*01(+) macaques were inoculated intravenously with three concentrated doses of single-cycle SIV (scSIV)....

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Bibliographische Detailangaben
Hauptverfasser: Evans, David T., Bricker, Jennifer E., Sanford, Hannah B., Lang, Sabine, Carville, Angela, Richardson, Barbra A., Piatak, Michael, Lifson, Jeffrey D., Mansfield, Keith G., Desrosiers, Ronald C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2005
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1143664/
https://ncbi.nlm.nih.gov/pubmed/15919923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.12.7707-7720.2005
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