Chimeric Dengue 2 PDK-53/West Nile NY99 Viruses Retain the Phenotypic Attenuation Markers of the Candidate PDK-53 Vaccine Virus and Protect Mice against Lethal Challenge with West Nile Virus

Chimeric dengue serotype 2/West Nile (D2/WN) viruses expressing prM-E of WN NY99 virus in the genetic background of wild-type D2 16681 virus and two candidate D2 PDK-53 vaccine variants (PDK53-E and PDK53-V) were engineered. The viability of the D2/WN viruses required incorporation of the WN virus-s...

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Hlavní autoři: Huang, Claire Y.-H., Silengo, Shawn J., Whiteman, Melissa C., Kinney, Richard M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2005
Témata:
Vaccines and Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1143654/
https://ncbi.nlm.nih.gov/pubmed/15919884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.12.7300-7310.2005
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