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Single Amino Acid Insertions at the Junction of the Sindbis Virus E2 Transmembrane Domain and Endodomain Disrupt Virus Envelopment and Alter Infectivity

The final steps in the envelopment of Sindbis virus involve specific interactions of the E2 endodomain with the virus nucleocapsid. Deleting E2 K at position 391 (E2 ΔK391) resulted in the disruption of virus assembly in mammalian cells but not insect cells (host range mutant). This suggested unique...

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Detalles Bibliográficos
Main Authors: Hernandez, Raquel, Ferreira, Davis, Sinodis, Christine, Litton, Katherine, Brown, Dennis T.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2005
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1143637/
https://ncbi.nlm.nih.gov/pubmed/15919921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.12.7682-7697.2005
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