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A case-control study of the HER2 Ile655Val polymorphism in relation to risk of invasive breast cancer

BACKGROUND: Overexpression of the HER2 proto-oncogene in human cancer cells has been associated with a poor prognosis, and survival improves with therapy targeting the HER2 gene. Animal studies and protein modeling suggest that the Ile655Val polymorphism located in the transmembrane domain of the HE...

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Bibliografske podrobnosti
Main Authors: Nelson, Stephanie E, Gould, Michael N, Hampton, John M, Trentham-Dietz, Amy
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2005
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1143556/
https://ncbi.nlm.nih.gov/pubmed/15987431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr1004
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