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H662 is the linchpin of ATP hydrolysis in the nucleotide-binding domain of the ABC transporter HlyB

The ABC transporter HlyB is a central element of the HlyA secretion machinery, a paradigm of Type I secretion. Here, we describe the crystal structure of the HlyB-NBD (nucleotide-binding domain) with H662 replaced by Ala in complex with ATP/Mg(2+). The dimer shows a composite architecture, in which...

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Bibliografiske detaljer
Main Authors: Zaitseva, Jelena, Jenewein, Stefan, Jumpertz, Thorsten, Holland, I Barry, Schmitt, Lutz
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2005
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1142601/
https://ncbi.nlm.nih.gov/pubmed/15889153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600657
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